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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPERA domain protein [4] with a mostly intracellular (ER membrane) localization. [5]
It acts through at least two types of receptors termed AT 1 and AT 2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin–angiotensin system. This receptor mediates programmed cell death .
The σ 1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). [13]
Low pressure baroreceptors are primarily involved in the regulation of the blood volume. Low pressure baroreceptors have both circulatory and renal effects, which produce changes in hormone secretion. Stimulation of these receptors causes the atria to release atrial natriuretic peptide. This hormone acts on the kidneys to increase sodium ...
551 11998 Ensembl ENSG00000101200 ENSMUSG00000037727 UniProt P01185 P35455 RefSeq (mRNA) NM_000490 NM_009732 RefSeq (protein) NP_000481 NP_033862 Location (UCSC) Chr 20: 3.08 – 3.08 Mb Chr 2: 130.42 – 130.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized ...
27346 69071 Ensembl ENSG00000109084 ENSMUSG00000037278 UniProt Q5BJF2 Q8VD00 RefSeq (mRNA) NM_014573 NM_133706 RefSeq (protein) NP_055388 NP_598467 Location (UCSC) Chr 17: 28.32 – 28.33 Mb Chr 11: 78.43 – 78.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sigma-2 receptor (σ 2 R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases ...
Baroreceptors respond very quickly to maintain a stable blood pressure, but their responses diminish with time and thus are most effective for conveying short term changes in blood pressure. In people with essential hypertension the baroreceptors and their reflexes change and function to maintain the elevated blood pressure as if normal.
Angiotensin II is the major bioactive product of the renin–angiotensin system, binding to receptors on intraglomerular mesangial cells, causing these cells to contract along with the blood vessels surrounding them; and to receptors on the zona glomerulosa cells, causing the release of aldosterone from the zona glomerulosa in the adrenal cortex.