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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.
Absolute lethal concentration, LC 100; Absolute lethal dose, LD 100 The most referenced value in the chemical industry is the median lethal dose, or LD50. This is the concentration of substance which resulted in the death of 50% of test subjects (typically mice or rats) in the laboratory.
A quantal dose response curve shows the percentage of subjects where a response is noted in an all-or-none manner (y axis) over the dose of the drug (x axis). For competition binding assays and functional antagonist assays IC 50 is the most common summary measure of the dose-response curve.
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
Prescriptions for lethal doses of medication in Oregon increased by nearly 30% in 2023, the same year an amendment to the state's Death with Dignity Act removed the in-state residency requirement ...
LT50 is the median Lethal Time (time until death) [1] [2] after exposure of an organism to a toxic substance or stressful condition. LT50 is commonly used in toxicology studies to quantify amount of a stressor necessary to kill an organism. LT50 can be used in conjunction with EC50 (median Exposure Concentration) for even more precise ...
Assignment to a toxicity class is based typically on results of acute toxicity studies such as the determination of LD 50 values in animal experiments, notably rodents, via oral, inhaled, or external application. The experimental design measures the acute death rate of an agent.