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7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
Anxiety about COVID-19 makes people more willing to "try anything" that might give them a sense of control of the situation, making them easy targets for scams. [5] Many false claims about measures against COVID-19 have circulated widely on social media, but some have been circulated by text, on YouTube, and even in some mainstream media ...
In Thai varieties of kratom, mitragynine is the most abundant component (up to 66% of total alkaloids), while 7-hydroxymitragynine (7-OH) is a minor constituent (up to 2% of total alkaloid content). In Malaysian kratom varieties, mitragynine is present at lower concentration (12% of total alkaloids). [ 5 ]
And why days 5 through 10 are so important.
Mitragynine pseudoindoxyl is a μ-opioid receptor agonist and δ-opioid receptor antagonist.It is a G protein biased agonist at the μ-opioid receptor, which may be responsible for its favorable side effect profile compared to conventional opioids. [3]
The authors came to the conclusion that no further trials of hydroxychloroquine or chloroquine for treatment of COVID-19 should be carried out. [58] On 26 April 2021, in its amended clinical management protocol for COVID-19, the Indian Ministry of Health lists hydroxychloroquine for use in patients during the early course of the disease. [23]
The principal for obstetric management of COVID-19 include rapid detection, isolation, and testing, profound preventive measures, regular monitoring of fetus as well as of uterine contractions, peculiar case-to-case delivery planning based on severity of symptoms, and appropriate post-natal measures for preventing infection.
It has an intrinsic activity between 99%-104% so we can say that 7-Hydroxymitragynine is a full agonist not a partial agonist like it was said before. The potency compared to morphine need to be revised too it's closer to 13 time the potency of morphine but with a far better oral bioavailability [ 1 ]