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CICs are different from progestogen-only injectable contraceptives (POICs), such as depot medroxyprogesterone acetate (DMPA; brand names Depo-Provera, Depo-SubQ Provera 104) and norethisterone enantate (NETE; brand name Noristerat), which are not combined with an estrogen and are given once every two to three months instead of once a month.
[1] [2] [3] The medication is given once a month by injection into muscle. [1] [2] [3] EV/NETE is approved for use in at least 36 countries, and is the most widely used combined injectable contraceptive. [5] [3] It is available widely throughout Latin America, in a few Asian and African countries, and in Turkey. [6] [7] [8]
By intramuscular injection, the elimination half-life of E2-EN has been found to be 5.6 to 7.5 days, while the half-life of algestone acetophenide and its metabolites has been found to be 24 days. [16] [17] [18] [2] Following a single injection, E2-EN and DHPA are detectable in the circulation for up to 30 to 60 days. [19] [2]
EC/MPA is available in the form of a microcrystalline aqueous suspension of 5 mg EC and 25 mg MPA given in a 0.5 mL aqueous solution for intramuscular injection once per month. [10] It is provided in the form of single-dose vials and ampoules. [10] The particle sizes of the formulation are 93% within a range of 5 to 16 μm. [11]
The patch is typically worn on the lower abdomen and replaced once a week. The failure rate for this is 7%. [1] The hormonal vaginal contraceptive ring is a ring that contains the hormones progestin and estrogen that a woman inserts into the vagina. It is replaced once a month and has a failure rate of 7%. [1]
You’ve probably heard of glucagon-like peptide 1 (aka GLP-1), given the rising popularity of weight loss injections and obesity-management medications. This hormone is released by the intestines ...
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Compounded semaglutide is a more affordable option, with monthly plans starting at $199 for those who qualify. ... Some folks might be perfectly okay doing once-weekly injections, but the idea of ...
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