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(A brief chemical gradient driven efflux of Na+ through the connexon at peak depolarization causes the conduction of cell to cell depolarization, not potassium.) [27] These connections allow for the rapid conduction of the action potential throughout the heart and are responsible for allowing all of the cells in the atria to contract together ...
Cellular mechanisms of early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs). Delayed afterdepolarizations (DADs) begin during phase 4, after repolarization is completed but before another action potential would normally occur via the normal conduction systems of the heart.
These cells will be initiating action potentials and contraction at a much lower rate than the primary or secondary pacemaker cells. The SA node controls the rate of contraction for the entire heart muscle because its cells have the quickest rate of spontaneous depolarization, thus they initiate action potentials the quickest.
Different wave shapes generated by different parts of the heart's action potential The ECG complex. P=P wave, PR=PR interval, QRS=QRS complex, QT=QT interval, ST=ST segment, T=T wave Principle of ECG formation. The red lines represent the depolarization wave, not bloodflow. An electrocardiogram is a recording of the electrical activity of the ...
Because the pacemaker potential represents the non-contracting time between heart beats , it is also called the diastolic depolarization. The amount of net inward current required to move the cell membrane potential during the pacemaker phase is extremely small, in the order of few pAs, but this net flux arises from time to time changing ...
Depolarization is essential to the function of many cells, communication between cells, and the overall physiology of an organism. Action potential in a neuron, showing depolarization, in which the cell's internal charge becomes less negative (more positive), and repolarization, where the internal charge returns to a more negative value.
In both cases, when stimulated by an action potential, voltage-gated channels rapidly open, beginning the positive-feedback mechanism of depolarization. This rapid influx of positively charged ions raises the membrane potential to approximately +30 mV, at which point the sodium channels close. The rapid depolarization period typically lasts 3 ...
When, at the end of a sinoatrial action potential, the membrane repolarizes below the I f threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase (DD); by this mechanism, the funny current controls the rate of spontaneous activity of ...
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