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Letrozole is contraindicated in women having a pre-menopausal hormonal status. Precautions are advised against becoming pregnant while using letrozole; on the loss of bone mineral density; on the increased level of cholesterol and fat in the blood; and on dizziness and against driving. [22] Breast feeding (lactation) is also counterindicated. [23]
By blocking the actions of orexins and modulating sleep–wake cycles, orexin receptor antagonists like daridorexant reduce wakefulness and improve sleep. [33] [16] [7] The sleep-promoting effects of dual orexin receptor antagonists are thought to be mediated specifically by blockade of the OX 2 receptor in the lateral hypothalamus. [16]
Also increased pneumonia risk exists in patients with esophageal dysphagia when compared to stroke patients because patients with stroke will improve as they recover from their acute injury, whereas esophageal dysphagia is likely to worsen with time. In one cohort of aspiration pneumonia patients, overall three-year mortality was 40%. [16]
Sleep paralysis may include hallucinations, such as an intruding presence or dark figure in the room. These are commonly known as sleep paralysis demons. It may also include suffocating or the individual feeling a sense of terror, accompanied by a feeling of pressure on one's chest and difficulty breathing. [9]
It is life-threatening in the elderly or those who are immunocompromised. [13] [14] The most common treatment is antibiotics and these vary in their adverse effects and their effectiveness. [13] [15] Pneumonia is also the leading cause of death in children less than five years of age in low income countries. [15]
Central hypoventilation syndrome (CHS) is a sleep-related breathing disorder that causes ineffective breathing, apnea, or respiratory arrest during sleep (and during wakefulness in severe cases). CHS can either be congenital (CCHS) or acquired (ACHS) later in life.
Surgical removal of enlarged tonsils (tonsillectomy) and the adenoid (adenoidectomy) are first line treatment among children with OSA. The operation is a common procedure but in the most extreme cases, children with severe OSA requires special precautions before, surgery (see "Surgery and obstructive sleep apnea syndrome" below).
Paralysis (pl.: paralyses; also known as plegia) is a loss of motor function in one or more muscles. Paralysis can also be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage.
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