Search results
Results from the WOW.Com Content Network
Drosophila is being used as a genetic model for several human diseases including the neurodegenerative disorders Parkinson's, Huntington's, spinocerebellar ataxia and Alzheimer's disease. [86] The fly is also being used to study mechanisms underlying aging and oxidative stress , immunity , diabetes , and cancer , as well as drug abuse .
The wing-spot test in D. melanogaster was first described by Graf and Würgler. [3] The wing-spot test determines for the induction of mutant spots that represent the loss of heterozygozity due to point mutation, deletion, nondisjunction, or mitotic recombination using the recessive genetic markers multiple wing hair (mwh) and flare-3 (flr3), located on chromosome number 3.
In the early phase of Carthew lab research, a number of firsts were achieved. The Carthew group was the first to establish the Drosophila eye as a model system to study planar cell polarity. [9] It was the first group to use Drosophila as a disease model to screen and test small molecule drugs for potential efficacy in disease treatment. [10]
Flightless fruit flies (Order Diptera) encompass a variety of different species of fly, such as Drosophila melanogaster, Bactrocera cucurbitae, Bactrocera dorsalis, and Drosophila hydei, with genetic mutations that cause them to be flightless. [1]
Drosophila melanogaster is commonly used for animal experimentation. Most animal testing involves invertebrates, especially Drosophila melanogaster, a fruit fly, and Caenorhabditis elegans, a nematode. These animals offer scientists many advantages over vertebrates, including their short life cycle, simple anatomy and the ease with which large ...
The fruit fly Drosophila melanogaster made the jump from nature to laboratory animal in 1901. At Harvard University, Charles W. Woodworth suggested to William E. Castle that Drosophila might be used for genetical work. [3] Castle, along with his students, then first brought the fly into their labs for experimental use.
The best known species of the Drosophilidae is Drosophila melanogaster, within the genus Drosophila, also called the "fruit fly." Drosophila melanogaster is used extensively for studies concerning genetics, development, physiology, ecology and behaviour. Many fundamental biological mechanisms were discovered first in D. melanogaster. [2]
The species of the model organism is usually chosen so that it reacts to disease or its treatment in a way that resembles human physiology, even though care must be taken when generalizing from one organism to another. [28] However, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models.