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Caplan syndrome presents with cough and shortness of breath in conjunction with features of rheumatoid arthritis, such as painful joints and morning stiffness. Examination should reveal tender, swollen metacarpophalangeal joints and rheumatoid nodules; auscultation of the chest may reveal diffuse crackles that do not disappear on coughing or taking a deep breath.
Methotrexate (green) complexed into the active site of DHFR (blue) Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.
Poison ivy. What it looks like: Poison ivy is a type of allergic contact dermatitis that is caused by the oil (urushiol oil) in the poison ivy plant, explains Karan Lal, D.O., M.S., F.A.A.D ...
Rheumatoid arthritis [2] Possibly collagen and/or citrullinated self proteins Chronic arthritis, inflammation, destruction of articular cartilage and bone Tuberculin reaction (Mantoux test) [3] Tuberculin Induration and erythema around injection site indicates previous exposure
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction. [1] Together with toxic epidermal necrolysis (TEN) and Stevens–Johnson/toxic epidermal necrolysis (SJS/TEN) overlap, they are considered febrile mucocutaneous drug reactions and probably part of the same spectrum of disease, with SJS being less severe.
A non-blanching rash (NBR) is a skin rash that does not fade when pressed with, and viewed through, a glass. It is a characteristic of both purpuric and petechial rashes. [ 1 ] Individual purpura measure 3–10 mm (0.3–1 cm, 3 ⁄ 32 - 3 ⁄ 8 in), whereas petechiae measure less than 3 mm. [ 2 ]
If the rash doesn’t go away after three or four days, if it gets worse, or if a fever develops, call your doctor. They may prescribe medication to help, Katta said. Show comments.
Eighty percent of adults [5] and sixty percent of children with juvenile dermatomyositis have a myositis-specific antibody (MSA). [6] Although no cure for the condition is known, treatments generally improve symptoms. [1] Treatments may include medication, physical therapy, exercise, heat therapy, orthotics, assistive devices, and rest. [1]