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Sprifermin (developmental code name AS-902330), [1] is a recombinant human fibroblast growth factor 18 (rhFGF18) analog, [2] which is under development by TrialSpark for the treatment of osteoarthritis. [3] FGF18 and sprifermin act via the Fibroblast Growth Factor Receptor (FGFR) family, with preferential activity via FGFR3c. [4]
Azficel-T, sold under the brand name Laviv, is a cell therapy product for the improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. [1] [2] [3] It consists of fibroblasts harvested from the patient's own skin.
A fibroblast is a type of biological cell typically with a spindle shape [1] that synthesizes the extracellular matrix and collagen, [2] produces the structural ...
Vosoritide works by binding to a receptor (target) called natriuretic peptide receptor type B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). [5] FGFR3 is a receptor that normally down-regulates cartilage and bone growth when activated by one of the proteins known as acidic and basic fibroblast growth factor.
BOS-580 is a long-acting fibroblast growth factor 21 analog that can be injected once monthly. [ 1 ] [ 2 ] [ 3 ] It was acquired by Boston Pharmaceuticals from Novartis in 2020. [ 4 ]
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen, sold under the brand name Stratagraft, is a medical treatment used for thermal burns containing intact dermal elements. [1] Common side effects include pruritus (itching), blisters, hypertrophic scar, and impaired healing (stalled healing process) at the treatment site ...
Foodborne illness costs Americans $75 billion annually in premature deaths, medical care and lost productivity, study finds.
Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the ...