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Intrinsic ageing and extrinsic ageing are terms used to describe cutaneous ageing of the skin and other parts of the integumentary system, which while having epidermal concomitants, seems to primarily involve the dermis. [1] Intrinsic ageing is influenced by internal physiological factors alone, and extrinsic ageing by many external factors.
[18] [43] Cancer invasiveness is promoted primarily through the actions of the SASP factors metalloproteinase, chemokine, interleukin 6 (IL-6), and interleukin 8 (IL-8). [52] [1] In fact, SASP from senescent cells is associated with many aging-associated diseases, including not only cancer, but atherosclerosis and osteoarthritis. [2]
Skin cancer is the uncontrolled proliferation of abnormal skin cells, usually developing on skin exposed to ultraviolet radiation. Squamous cell carcinoma , basal cell carcinoma , and melanoma are the three main types of skin cancer, [ 5 ] with the former two being non-melanoma skin cancer.
Aging is characterized by the declining ability to respond to stress, increased homeostatic imbalance, and increased risk of aging-associated diseases including cancer and heart disease. Aging has been defined as "a progressive deterioration of physiological function, an intrinsic age-related process of loss of viability and increase in ...
DNA cross-linking can in turn lead to various effects of aging, especially cancer. [21] Other cross-linking can occur between fat and protein molecules, which leads to wrinkles. [22] Free radicals can oxidize LDL, and this is a key event in the formation of plaque in arteries, leading to heart disease and stroke. [23]
Passive smoking also impairs a proper wound healing process. [66] Age – Increased age (over 60 years) is a risk factor for impaired wound healing. [64] It is recognized that, in older adults of otherwise overall good health, the effects of aging causes a temporal delay in healing, but no major impairment with regard to the quality of healing ...
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
Ageing is associated with increased risk of cancer, Alzheimer's disease, diabetes, cardiovascular disease, increased mental health risks, and many more. [ 4 ] [ 5 ] Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. [ 6 ]