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Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across ...
The first part of the ear to develop is the inner ear, [19] which begins to form from the ectoderm around the embryo's 22nd day, [18] derived from two thickenings called otic placodes on either side of the head. Each otic placode recedes below the ectoderm, forms an otic pit and then an otic vesicle. [20]
The ear, including both the vestibular system and the auditory system, develops from the otic placode beginning the third week of development. During the fourth week, the otic placode invaginates into the mesenchyme adjacent to the rhombencephalon to form the otic pit, which then pinches off from the surface ectoderm to form the otic vesicle. [1]
Only the epidermis in the head is competent to respond to the signal from the optic vesicles. Both the optic vesicle and the head epidermis are required for eye development. The competence of the head epidermis to respond to the optic vesicle signals comes from the expression of Pax6 in the epidermis. Pax6 is necessary and sufficient for eye ...
The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.