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The Jerusalem artichoke (Helianthus tuberosus), also called sunroot, sunchoke, wild sunflower, [3] topinambur, [3] or earth apple, is a species of sunflower native to central North America. [4] [5] It is cultivated widely across the temperate zone for its tuber, which is used as a root vegetable. [6]
The artichoke is a domesticated variety of the wild cardoon (Cynara cardunculus), [9] which is native to the Mediterranean area. [1] There was debate over whether the artichoke was a food among the ancient Greeks and Romans, or whether that cultivar was developed later, with Classical sources referring instead to the wild cardoon.
Lisinopril/amlodipine is a combination of two agents which both act to induce vascular smooth muscle relaxation to lower blood pressure in distinct ways: [1]. Lisinopril inhibits angiotensin converting enzyme (ACE), the enzyme responsible for converting angiotensin I into angiotensin II (a vasoconstrictor).
Cynaropicrin is a sesquiterpene lactone of the guaianolide type found mainly in leaves of artichoke plants. It is one of the compounds that gives the artichoke its characteristic bitterness. It is found in artichoke leaves with an abundance of approximately 87 g/kg, but can hardly be found in other parts of the plant. [1]
For calcium labeling purposes 100% of the Daily Value was 1000 mg, but in May 2016 it was revised to 1000–1300 mg. [50] A table of the pre-change adult Daily Values and references for the revision are provided at Reference Daily Intake. Food and supplement companies had until July 2018 to comply with the labeling change. [50]
EE/CPA comes in the form of oral tablets and contains 35 or 50 μg EE and 2 mg CPA per tablet. [2] It is taken once daily for 21 days, followed by a 7-day free interval. [ 2 ]
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