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The reversal potential of the GABA B-mediated IPSP (inhibitory postsynaptic potential) is −100 mV, which is much more hyperpolarized than the GABA A IPSP. GABA B receptors are found in the central nervous system and the autonomic division of the peripheral nervous system. [2]
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential. [1] The opposite of an inhibitory postsynaptic potential is an excitatory postsynaptic potential (EPSP), which is a synaptic potential that makes a postsynaptic neuron more likely to generate an action potential.
By contrast, IPSPs are induced by the binding of GABA(gamma-aminobutyric acid), or glycine. [4] Synaptic potentials are small and many are needed to add up to reach the threshold. This means a single EPSP/IPSP is typically not enough to trigger an action potential.
Presynaptic inhibition occurs when an inhibitory neurotransmitter, like GABA, acts on GABA receptors on the axon terminal. Or when endocannabinoids act as retrograde messengers by binding to presynaptic CB1 receptors , thereby indirectly modulating GABA and the excitability of dopamine neurons by reducing it and other presynaptic released ...
[39] [40] However, since GABA С receptors are closely related in sequence, structure, and function to GABA A receptors and since other GABA A receptors besides those containing ρ subunits appear to exhibit GABA С pharmacology, the Nomenclature Committee of the IUPHAR has recommended that the GABA С term no longer be used and these ρ ...
[9] [10] The gradient of chloride was reported to be reversed in immature neurons, with its reversal potential higher than the resting membrane potential of the cell; activation of a GABA-A receptor thus leads to efflux of Cl − ions from the cell (that is, a depolarizing current). The differential gradient of chloride in immature neurons was ...
The GABA B receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism of action differs significantly from the ionotropic receptors. Functionally, in mature organisms, activation of these receptors typically results in neural inhibition, primarily via the influx of chloride ions , although exceptions to ...
The reversal potential of the GABA A-mediated inhibitory postsynaptic potential (IPSP) in normal solution is −70 mV, contrasting the GABA B IPSP (−100 mV). The active site of the GABA A receptor is the binding site for GABA and several drugs such as muscimol, gaboxadol, and bicuculline. [6]