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General "Fightin' Joe" Hooker Union General Joseph Hooker (seated 2nd to right) and his staff, 1863. Hooker's plan for the spring and summer campaign was both elegant and promising. He first planned to send his cavalry corps deep into the enemy's rear, disrupting supply lines and distracting him from the main attack.
It became available in 1912 and superseded the more toxic and less water-soluble Salvarsan as an effective treatment for syphilis. Because both of these arsenicals carried considerable risk of side effects, they were replaced for this indication by penicillin in the 1940s.
Unpleasant side effects of mercury treatment included gum ulcers and loose teeth. [68] Mercury continued to be used in syphilis treatment for centuries; an 1869 article by Thomas James Walker, M. D., discussed administering mercury by injection for this purpose. [69] The discovery of guaiacum as cure for syphilis, after Stradanus, 1590
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
Both Jarisch and Herxheimer observed reactions in patients with syphilis treated with mercury. The reaction was first seen following treatment in early and later stages of syphilis treated with Salvarsan, mercury, or antibiotics. Jarisch thought that the reaction was caused by a toxin released from the dying spirochetes. [11]
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum, a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...
The treatment group was given orvus-mapharsen or penicillin to see its effects, and the control group was given nothing to stop the disease. [29] The researchers paid prostitutes infected with syphilis to have sex with prisoners, while other subjects were infected by directly inoculating them with the bacterium. [6]