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Ribociclib, sold under the brand name Kisqali, is a medication used for the treatment of certain kinds of breast cancer. [4] Ribociclib is a kinase inhibitor. [ 4 ] It was developed by Novartis and Astex Pharmaceuticals .
[64] [58] Symptoms that may indicate liver dysfunction include nausea, vomiting, abdominal pain, fatigue, anorexia, "flu-like" symptoms, dark urine, and jaundice. [64] As of 2022, at least 10 case reports of bicalutamide-associated hepatotoxicity or liver failure, two of which were fatal, have been published in the literature.
Kisqali, on the other hand, will be available to a much broader group of patients, whose disease may not be as aggressive at the time of diagnosis. ... It may also cause fewer side effects ...
Symptoms may include tinnitus, [29] [125] psychosis, cognitive deficits, gastrointestinal complaints, insomnia, paraesthesia (tingling and numbness), pain (usually in limbs and extremities), muscle pain, weakness, tension, painful tremor, shaking attacks, jerks, dizziness and blepharospasm [20] and may occur even without a pre-existing history ...
Weight gain is an increase in body weight. This can involve an increase in muscle mass , fat deposits , excess fluids such as water or other factors. Weight gain can be a symptom of a serious medical condition.
Some patients (especially younger ones) gain weight due to excessive appetite stimulation that exceeds the weight loss effect. [11] Increased appetite. [4] Increased sweating [11] Heat intolerance [11] Abnormal breast enlargement in men [12] Augmented calcium levels in the blood (by as much as 25% – known as hypercalcaemia). This can cause ...
While fatigue is often prominent, it is "more than fatigue following a stressor". [6] Other symptoms that may occur during PEM include cognitive impairment, flu-like symptoms, pain, weakness, and trouble sleeping. [6] [4] Though typically cast as a worsening of existing symptoms, patients may experience some symptoms exclusively during PEM. [6]
Cachexia (/ k ə ˈ k ɛ k s i ə / [1]) is a syndrome that happens when people have certain illnesses, causing muscle loss that cannot be fully reversed with improved nutrition. [2] It is most common in diseases like cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease, and AIDS.