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With the resultant oxygen tension and diminished blood supply reaching the outer hair cells, their response to sound levels is lessened when exposed to loud sounds, rendering them less effective and putting more stress on the inner hair cells. [4] This can lead to fatigue and temporary hearing loss if the outer hair cells do not get the ...
The inner hair cells are the primary sensory receptors and a significant amount of the sensory input to the auditory cortex occurs from these hair cells. Outer hair cells on the other hand boost the mechanical signal by using electromechanical feedback.
Deflections of the stereocilia in the opposite direction toward the shortest stereocilia causes transduction channels to close. In this situation, the hair cells become hyperpolarized and the nerve afferents are not excited. [7] [8] [9] There are two different types of fluid that surround the hair cells of the inner ear.
The opposing effects caused by a tilt of the head cause differential sensory inputs from the hair cell bundles allowing humans to tell which way the head is tilting. [8] Sensory information is then sent to the brain, which can respond with appropriate corrective actions to the nervous and muscular systems to ensure that balance and awareness ...
There are two types of hair cells specific to the auditory system; inner and outer hair cells. Inner hair cells are the mechanoreceptors for hearing: they transduce the vibration of sound into electrical activity in nerve fibers, which is transmitted to the brain. Outer hair cells are a motor structure. Sound energy causes changes in the shape ...
In mammalian outer hair cells, the varying receptor potential is converted to active vibrations of the cell body. This mechanical response to electrical signals is termed somatic electromotility; [13] it drives variations in the cell's length, synchronized to the incoming sound signal, and provides mechanical amplification by feedback to the traveling wave.
Hair cells die of old age, acoustic overstimulation and other traumas. [2] Oxotoxin exposure, such as aminoglycoside antibiotics and cisplatin, is also a major contributor to hair cell death. [7] Because mammals have very limited hair cell regeneration, hearing loss is essentially irreversible and therefore a therapeutic target for regeneration.
Tiny cells in the inner ear, called hair cells, are responsible for hearing and balance. States of neuropathic pain, such as hyperalgesia and allodynia, are also directly related to mechanosensation. A wide array of elements are involved in the process of mechanosensation, many of which are still not fully understood.