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Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.
This page was last edited on 1 February 2024, at 10:05 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Thiamine is one of the B vitamins and is also known as vitamin B 1. [1] [11] [12] It is a cation that is usually supplied as a chloride salt. [3]It is soluble in water, methanol and glycerol, but practically insoluble in less polar organic solvents.
List of B vitamins Vitamin Name Description Vitamin B 1: Thiamine: A coenzyme in the catabolism of sugars and amino acids.: Vitamin B 2: Riboflavin: A precursor of coenzymes called FAD and FMN, which are needed for flavoprotein enzyme reactions, including activation of other vitamins
Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
The results included sulbutiamine, fursultiamine (thiamine tetrahydrofurfuryl disulfide) and benfotiamine. These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduced to thiamine by cysteine or glutathione. [7]: 302 [8] It was first marketed in France by Servier in 1973 under the brand name Arcalion.
B1 is typically only water soluble. Note that a substance can also be fat and water soluble, although there is no indication that benfotiamine is such a substance. --IO Device 18:42, 6 November 2011 (UTC) benfotiamine is a fat soluble form of thiamine. B1 is tradiitonally considered water soluble because most B1 is in the thiamine form.
This page was last edited on 7 September 2019, at 03:49 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
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