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  2. Induced pluripotent stem cell - Wikipedia

    en.wikipedia.org/wiki/Induced_pluripotent_stem_cell

    Embryoid body: hESCs in culture spontaneously form ball-like embryo-like structures termed "embryoid bodies", which consist of a core of mitotically active and differentiating hESCs and a periphery of fully differentiated cells from all three germ layers. iPSCs also form embryoid bodies and have peripheral differentiated cells.

  3. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

  4. Embryonic stem cell - Wikipedia

    en.wikipedia.org/wiki/Embryonic_stem_cell

    For example ESCs have been differentiated into insulin-producing cells, [26] and researchers at Harvard University were able to produce large quantities of pancreatic beta cells from ESCs. [ 27 ] An article published in the European Heart Journal describes a translational process of generating human embryonic stem cell-derived cardiac ...

  5. P53 p63 p73 family - Wikipedia

    en.wikipedia.org/wiki/P53_p63_p73_family

    The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]

  6. TP53BP1 - Wikipedia

    en.wikipedia.org/wiki/TP53BP1

    Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene. [ 5 ] [ 6 ] [ 7 ] Clinical significance

  7. Human papillomavirus infection - Wikipedia

    en.wikipedia.org/wiki/Human_papillomavirus_infection

    Thus, the degradation of p53, induced by E6, promotes unregulated cell division, cell growth and cell survival, all characteristics of cancer. [ 49 ] It is important to note, that while the interaction between E6, E6AP, and p53 was the first to be characterized, there are multiple other proteins in the host cell which interact with E6 and ...

  8. Caretaker gene - Wikipedia

    en.wikipedia.org/wiki/Caretaker_gene

    An example of one such gene is p53. Patients with Li-Fraumeni syndrome , for example, have mutations in the p53 gene that suggest caretaker function. p53 has an identified role, however, in regulating the cell cycle as well, which is an essential gatekeeper function.

  9. Suicide gene - Wikipedia

    en.wikipedia.org/wiki/Suicide_gene

    In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.