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  2. Adrenoleukodystrophy - Wikipedia

    en.wikipedia.org/wiki/Adrenoleukodystrophy

    Adrenoleukodystrophy (ALD) is a disease linked to the X chromosome. It is a result of fatty acid buildup caused by failure of peroxisomal fatty acid beta oxidation which results in the accumulation of very long chain fatty acids in tissues throughout the body.

  3. X-linked adrenoleukodystrophy (X-ALD) affects the nervous system and the adrenal cortex. The involvement of nervous system and adrenal gland is independent and determines whether the affected male is diagnosed with cerebral disease, adrenomyeloneuropathy, or primary adrenocortical insufficiency.

  4. X-linked adrenoleukodystrophy - MedlinePlus

    medlineplus.gov/genetics/condition/x-linked-adrenoleukodystrophy

    X-linked adrenoleukodystrophy is a genetic disorder that mainly affects the nervous system and the adrenal glands, which are located on top of each kidney. In this disorder, the fatty covering that insulates nerves in the brain and spinal cord tends to deteriorate (a condition called demyelination). The loss of myelin reduces the ability of the ...

  5. Adrenoleukodystrophy - Symptoms and causes - Mayo Clinic

    www.mayoclinic.org/diseases-conditions/adrenoleukodystrophy/symptoms-causes/...

    In adrenoleukodystrophy (ALD), your body can't break down very long-chain fatty acids (VLCFAs), causing saturated VLCFA s to build up in your brain, nervous system and adrenal gland. The most common type of ALD is X-linked ALD, which is caused by a genetic defect on the X chromosome.

  6. X-linked adrenoleukodystrophy | Radiology Reference Article ...

    radiopaedia.org/articles/x-linked-adrenoleukodystrophy-1?lang=us

    X-linked adrenoleukodystrophy is an inherited metabolic peroxisomal disorder and one of the more common leukodystrophies in both children and adults.

  7. X-linked adrenoleukodystrophy | About the Disease | GARD

    rarediseases.info.nih.gov/diseases/5758/x-linked-adrenoleukodystrophy

    X-linked adrenoleukodystrophy (X-ALD) is a genetic disease that affects the brain and the adrenal glands (small glands located on top of each kidney). It is caused by variations in the ABCD1 gene that lead to an inability to break down very long–chain fatty acids (VLCFAs) which can accumulate in the brain and adrenal glands.

  8. X-Linked Adrenoleukodystrophy - Symptoms, Causes, Treatment |...

    rarediseases.org/rare-diseases/adrenoleukodystrophy

    X-linked adrenoleukodystrophy (ALD) is a rare genetic disorder that affects the white matter of the nervous system and the adrenal cortex. White matter is made up of nerve fibers called axons that relay nerve impulses from one cell to another.

  9. Adrenoleukodystrophy - StatPearls - NCBI Bookshelf

    www.ncbi.nlm.nih.gov/books/NBK562328

    Adrenoleukodystrophy is usually X-linked (X-ALD) and caused by over 2700 known mutations in the gene mutations. The gene plays a significant role in the VLCFA transport system into peroxisomes, where VLCFAs can undergo further metabolism.

  10. Management and prognosis of X-linked adrenoleukodystrophy

    sso.uptodate.com/.../management-and-prognosis-of-x-linked-adrenoleukodystrophy

    X-linked adrenoleukodystrophy (ALD) is a peroxisomal disorder of beta-oxidation that results in accumulation of very long-chain fatty acids (VLCFAs) in all tissues. Patients with ALD are asymptomatic at birth but may develop adrenal failure, leukodystrophy, and/or myeloneuropathy (spinal cord disease and peripheral neuropathy).

  11. X‐linked adrenoleukodystrophy: Pathology, pathophysiology,...

    www.ncbi.nlm.nih.gov/pmc/articles/PMC7041623

    X‐linked adrenoleukodystrophy, ALD, (MIM #300100) is the most common peroxisomal disorder affecting both males and females with an estimated birth incidence of about 1/14,700 (Bezman et al., 2001; Moser et al., 2016).