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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.
Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...
Online video platforms allow users to upload, share videos or live stream their own videos to the Internet. These can either be for the general public to watch, or particular users on a shared network. The most popular video hosting website is YouTube, 2 billion active until October 2020 and the most extensive catalog of online videos. [1]
In the ROCKET-AF trial, a Bayer company based double blind trial, comparing a once-daily, fixed dose (20 mg daily or 15 mg daily in patients with a creatinine clearance of 30 to 49 ml per minute) of rivaroxaban with adjusted-dose warfarin in patients with nonvalvular atrial fibrillation who were at moderate-to-high risk for stroke, rivaroxaban ...
The FAST ecosystem has several layers. The best-known FASTs are the aggregators, which fall into three categories. FASTs owned by major media companies: Paramount's Pluto TV, Fox's Tubi, Charter Communications and Comcast's Xumo Play, Dish Network's Sling Freestream, ITV’s ITVX service, ABS-CBN's Kapamilya Online Live, [3] GMA Network's Kapuso Stream, [4] NEW ID's BINGE Korea, [5] Allen ...
An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.
Various networks and news outlets in North America have provided official live video streams of news for most or all of the day, as described below. The ABC Television Network has provided a live streaming service of world news, known as "ABC News Live," for eighteen hours per day, since 2018. This is available via ABC's official platform on ...