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A radio-receptor assay requires the separation of the bound from the free ligand. This is done by filtration, centrifugation or dialysis. [2] A method that does not require separation is the scintillation proximity assay that relies on the fact that β-rays from 3 H travel extremely short distances. The receptors are bound to beads coated with ...
K i is the inhibition constant for a drug; the concentration of competing ligand in a competition assay which would occupy 50% of the receptors if no ligand were present. [ 5 ] The Cheng-Prusoff equation produces good estimates at high agonist concentrations, but over- or under-estimates K i at low agonist concentrations.
I-Doser is an application for the playback of proprietary audio content. The developer claims the separately purchasable content aims to simulate specific mental states through the use of binaural beats, some of it is named after various recreational drugs. [1]
In 1979, Johann Gasteiger and Mario Marsili published a method for the iterative calculation of atomic partial charges in molecules. [3] This work is his most-cited publication. [ 4 ] Between 1987 and 1991 Johann Gasteiger was a project manager for the development of the ChemInform RX database.
The U.S. Food and Drug Administration also has guidance to elucidate dose–response relationships [3] during drug development. Dose response relationships may be used in individuals or in populations. The adage The dose makes the poison reflects how a small amount of a toxin has no significant effect, while a large amount may be fatal. This ...
Lipophilic efficiency [1] (LiPE), sometimes referred to as ligand-lipophilicity efficiency (LLE) is a parameter used in drug design and drug discovery to evaluate the quality of research compounds, linking potency and lipophilicity in an attempt to estimate druglikeness.
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Download QR code; Print/export Download as PDF; Printable version ... C avg is the average concentration of a drug in the central circulation during a dosing interval ...