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For example, in clinical trials, the drug strontium ranelate was found to aid bone growth, increase bone density, and lessen vertebral, peripheral, and hip fractures in women. Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of ...
Strontium belongs to the same periodic family as calcium (alkaline earth metals), and is metabolised in a similar fashion, preferentially targeting metabolically active regions of the bone. 89 Sr is an artificial radioisotope used in the treatment of osseous (bony) metastases of bone cancer. [8] [9]
A bone seeker is an element, often a radioisotope, that tends to accumulate in the bones of humans and other animals when introduced into the body. For example, strontium and radium are chemically similar to calcium and can replace the calcium in bones.
The strontium radioisotopes are very important, as strontium is a calcium mimic which is incorporated in bone growth and therefore has a great ability to harm humans. On the other hand, this also allows 89 Sr to be used in the open source radiotherapy of bone tumors .
The former has a half-life of 50.6 days and is used to treat bone cancer due to strontium's chemical similarity and hence ability to replace calcium. [23] [24] While 90 Sr (half-life 28.90 years) has been used similarly, it is also an isotope of concern in fallout from nuclear weapons and nuclear accidents due to its production as a fission ...
As strontium is water-soluble, the perovskite form strontium titanate is usually employed as it is not water-soluble and has a high melting point. [2] Strontium-89 is a short-lived beta emitter which has been used as a treatment for bone tumors, this is used in palliative care in terminal cancer cases.
Radium-223 chloride, strontium-89 chloride and samarium-153 EDTMP are used to treat secondary cancer in the bones. [9] [10] Radium and strontium mimic calcium in the body. [11] Samarium is bound to tetraphosphate EDTMP, phosphates are taken up by osteoblastic (bone forming) repairs that occur adjacent to some metastatic lesions. [12]
A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). [1] [4] Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. [1] There may be a lump, pain, or neurological signs from pressure. [1]
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