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  2. Congenital insensitivity to pain - Wikipedia

    en.wikipedia.org/wiki/Congenital_insensitivity...

    A patient and doctor discuss congenital insensitivity to pain. For people with this disorder, cognition and sensation are otherwise normal; for instance, patients can still feel discriminative touch (though not always temperature [3]), and there are generally no detectable physical abnormalities.

  3. Congenital insensitivity to pain with anhidrosis - Wikipedia

    en.wikipedia.org/wiki/Congenital_insensitivity...

    Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature and prevents a person from sweating. Cognitive disorders are commonly coincidental.

  4. Marsili syndrome - Wikipedia

    en.wikipedia.org/wiki/Marsili_syndrome

    1960: Ervin and Sternbach describe 6 members from a 2-generation family with dominantly-inherited congenital insensitivity to pain. [ 4 ] 1974: Comings and Amromin describe 3 members from a 2-generation family which consisted of a mother, her son and her daughter with the symptoms characteristic of Marsili syndrome, there was a possibility that ...

  5. Hereditary sensory and autonomic neuropathy - Wikipedia

    en.wikipedia.org/wiki/Hereditary_sensory_and...

    Type 4, congenital insensitivity to pain with anhidrosis (CIPA), is an autosomal recessive condition and affected infants present with episodes of hyperthermia unrelated to environmental temperature, anhidrosis and insensitivity to pain. Palmar skin is thickened and charcot joints are commonly present.

  6. Paroxysmal extreme pain disorder - Wikipedia

    en.wikipedia.org/wiki/Paroxysmal_extreme_pain...

    Paroxysmal extreme pain disorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing. PEPD often first manifests at the beginning of life, perhaps even in utero, with symptoms persisting throughout life.

  7. Words are overrated. Here’s why we’re addicted to ‘silent ...

    www.aol.com/words-overrated-why-addicted-silent...

    Get inspired by a weekly roundup on living well, made simple. Sign up for CNN’s Life, But Better newsletter for information and tools designed to improve your well-being.

  8. Katie Holmes Recalls What Happened When She Forgot Her Lines ...

    www.aol.com/katie-holmes-recalls-happened-she...

    Katie Holmes understands the show must go on. The actress stopped by The Tonight Show Starring Jimmy Fallon Nov. 27 to discuss her role playing Mrs. Webb in the Broadway revival of Our Town.Holmes ...

  9. Congenital Insensitivity to Pain (CIP) is a genetic disorder causing channelopathy while Congenital Insensitivity to Pain with Anhydrosis (CIPA) is a genetic disorder of affecting the formation of nerve growth factor, or other genetic disorders.