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Streptomycin also is used as a pesticide, to combat the growth of bacteria beyond human applications. Streptomycin controls bacterial diseases of certain fruit, vegetables, seed, and ornamental crops. A major use is in the control of fireblight on apple and pear trees. As in medical applications, extensive use can be associated with the ...
Streptomycin is noteworthy because it is the first significant antibiotic discovered after penicillin, the first systemic antibiotic discovered in America, the first antibiotic active against tuberculosis, and the first-line treatment for plague.
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class.
Streptomycin: Tuberculosis: Spectinomycin(Bs) Trobicin: Gonorrhea: Ansamycins; Geldanamycin: Experimental, as antitumor antibiotics: Block DNA transcription, either via inhibiting DNA-dependent RNA polymerase by binding to the β-subunit Herbimycin: Rifaximin: Xifaxan: Traveler's diarrhea caused by E. coli: Carbacephem; Loracarbef: Lorabid ...
The US Patent Office granted U.S. patent 2,449,866 titled "Improvement in Streptomycin and Processes of Preparation" to Schatz and Waksman on 21 September 1948. [6] Merck was to get an exclusive right for commercial production. [32] Schatz was the lead author of the paper on streptomycin discovery with Bugie as the second.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines.Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. [1]
This was the original source of many antibiotics, namely streptomycin, the first antibiotic against tuberculosis. Genomics ...