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CIPN afflicts between 30% and 40% of patients undergoing chemotherapy. Antineoplastic agents in chemotherapy are designed to eliminate rapidly dividing cancer cells, but they can also damage healthy structures, including the peripheral nervous system. [1] CIPN involves various symptoms such as tingling, pain, and numbness in the hands and feet. [2]
The symptoms can occur anywhere between days to months after administration of the offending medication, depending on the dose and speed of administration. [3] [4] The patient first experiences tingling and/or numbness of the palms and soles. This is followed 2–4 days later by bright redness, which is symmetrical and sharply defined. [5]
Peripheral neuropathy may first be considered when an individual reports symptoms of numbness, tingling, and pain in feet. After ruling out a lesion in the central nervous system as a cause, a diagnosis may be made on the basis of symptoms, laboratory and additional testing, clinical history, and a detailed examination.
It usually begins in the hands and feet and may progress to the arms and legs and sometimes to other parts of the body where it may affect the autonomic nervous system. It may be acute or chronic. A number of different disorders may cause polyneuropathy, including diabetes and some types of Guillain–Barré syndrome. [4] [5] [6]
Paresthesias of the hands, feet, legs, and arms are common transient symptoms. The briefest electric shock type of paresthesia can be caused by tweaking the ulnar nerve near the elbow; this phenomenon is colloquially known as bumping one's "funny bone". Similar brief shocks can be experienced when any other nerve is tweaked (e.g. a pinched neck ...
Other symptoms to note: With rosacea, skin might feel rough, bumpy, or warm to the touch. Redness usually appears on the forehead, nose, cheeks, and chin. Redness usually appears on the forehead ...
Others describe a feeling akin to having a pebble in the shoe or walking on razor blades. Burning, numbness, and paresthesia may also be experienced. [9] The symptoms progress over time, often beginning as a tingling sensation in the ball of the foot. [10] Morton's neuroma lesions have been found using MRI in patients without symptoms. [11]
Manhattan-based dermatologist Dr. Brendan Camp, M.D., said that toasted skin syndrome, officially known as erythema ab igne (EAI), is a "pattern of discoloration that occurs in areas of skin after ...