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Biotin deficiency is a nutritional disorder which can become serious, even fatal, if allowed to progress untreated. It can occur in people of any age, ancestry, or of ...
Biotinidase deficiency is an autosomal recessive metabolic disorder in which biotin is not released from proteins in the diet during digestion or from normal protein turnover in the cell. This situation results in biotin deficiency. Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins.
Biotin requirements vary by age and life stage, but most adults need roughly 30 micrograms per day. While rare, biotin deficiency can lead to symptoms such as thinning hair, skin rashes, brittle ...
Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face. [2] [4] Aside from inadequate dietary intake (rare), deficiency of biotin can be caused by a genetic disorder that affects biotin metabolism. The most common among these is biotinidase deficiency.
Biotinidase deficiency is an inherited disorder caused by mutations in the BTD gene. When biotinidase activity is deficient, biotin can be neither recycled within the body nor removed from ingested food. Nor can biotin be recycled from enzymes to which it is bound.
Signs of a biotin deficiency may appear gradually, per the NIH. In the later stages, a biotin deficiency can cause: Hair thinning. Hair loss. A scaly, red rash around orifices. Dry, red eyes ...
In the U.S., as many as 43 percent of older adults have vitamin B12 deficiency. Symptoms of insufficient vitamin B12 can include fatigue, palpitations, pale skin, numbness, weight loss ...
The signs and symptoms of holocarboxylase synthetase deficiency typically appear within the first few months of life, but the age of onset varies. Affected infants often have immunodeficiency diseases, difficulty feeding, breathing problems, a skin rash, hair loss , and a lack of energy . Immediate treatment and lifelong management (using ...