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The equilibrium is not complete because the acidity difference between guanidinium and water is not large. The approximate pK a values: 13.6 vs 15.7. Complete deprotonation should be done with extremely strong bases, such as lithium diisopropylamide. C(NH 2) + 3 Cl − + Li + N(C 3 H 7) − 2 → HNC(NH 2) 2 + HN(C 3 H 7) 2 + LiCl
Guanidine exists protonated, as guanidinium, in solution at physiological pH. Guanidinium chloride (also known as guanidine hydrochloride) has chaotropic properties and is used to denature proteins. Guanidinium chloride is known to denature proteins with a linear relationship between concentration and free energy of unfolding.
barium chloride: 10361–37–2 BaCl 2 •2H 2 O: barium chloride dihydrate: 10326–27–9 BaCrO 4: barium chromate: 10294–40–3 BaF 2: barium fluoride: 7787–32–8 Ba(HS) 2: barium hydrosulfide: 25417–81–6 BaH 2: barium hydride: 13477–09–3 BaHgI 4: barium tetraiodomercurate: 10048–99–4 BaI 2: barium iodide: 13718–50–8 BaI ...
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
A chaotropic agent is a substance which disrupts the structure of, and denatures, macromolecules such as proteins and nucleic acids (e.g. DNA and RNA).Chaotropic solutes increase the entropy of the system by interfering with intermolecular interactions mediated by non-covalent forces such as hydrogen bonds, van der Waals forces, and hydrophobic effects.
Sean Duffy speaks during a Senate Commerce, Science, and Transportation committee hearing on his nomination to be Secretary of Transportation on Wednesday, Jan. 15, 2025 in Washington, DC.
The pulmonary toxicity of PHMG was discovered due to an outbreak of lung diseases in South Korea, detected in children between 2006 and 2011, and in adults in the spring of 2011; the mortality rate in children was 58%, while among adults, 53% died or required lung transplantation. [4]
Canada will take legal action under the relevant international bodies to challenge the 25% tariffs imposed by the United States on most Canadian goods, a senior government official said on Sunday ...