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Trazodone is usually used at a dosage of 150 to 300 mg/day for the treatment of depression. [17] [13] Lower doses have also been used to augment other antidepressants or when initiating therapy. [17] [13] Higher doses, up to 600 mg/day, have been used in more severe cases of depression (in hospitalized patients, for example). [29]
This is a list of adverse effects of the antidepressant trazodone, ... [1] [2] [3] Very common. Very common (>10% incidence) adverse effects include: Blurred vision;
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone. Serotonin antagonist and reuptake inhibitors ( SARIs ) are a class of drugs used mainly as antidepressants , but also as anxiolytics and hypnotics .
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Due to its long elimination half-life, triazoledione is the major metabolite and predominates in the circulation during nefazodone treatment, with plasma levels that are 4 to 10 times higher than those of nefazodone itself. [2] [35] Conversely, hydroxynefazodone levels are about 40% of those of nefazodone at steady state. [2]
Midodrine is a prodrug of its active metabolite desglymidodrine. [3] [1] This metabolite acts as a selective agonist of the α 1-adrenergic receptor. [3] [1] This in turn results in vasoconstriction and increased blood pressure. [3] [1] Midodrine was discovered by 1971 [6] and was introduced for medical use in the United States in 1996 ...
There has been much debate as to whether reboxetine is more efficacious than placebo in the treatment of depression. According to a 2009 meta-analysis of 12 second-generation antidepressants, reboxetine was no more effective than placebo, and was "significantly less" effective and less acceptable than the other drugs in treating the acute-phase of adults with unipolar major depression.