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Much evidence suggests that many of the long-term complications of diabetes, result from many years of hyperglycemia (elevated levels of glucose in the blood). [11] "Perfect glycemic control" would mean that glucose levels were always normal (70–130 mg/dL or 3.9–7.2 mmol/L) and indistinguishable from a person without diabetes.
Insulin was first used as a medication in Canada by Charles Best and Frederick Banting in 1922. [63] It is listed on the World Health Organization's List of Essential Medicines. [64] In 2017, it ranked as the 209th most commonly prescribed medication in the United States, with over 2 million prescriptions. [65]
During pregnancy, spontaneous hyperglycemia can develop and lead to gestational diabetes mellitus (GDM), a frequent pregnancy complication . With a prevalence of 6-20% among pregnant women globally, gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance developing or initially recognized during pregnancy. [67]
Chronic hyperglycemia at above normal levels can produce a very wide variety of serious complications over a period of years, including kidney damage, neurological damage, cardiovascular damage, damage to the retina or damage to feet and legs. Diabetic neuropathy may be a result of long-term hyperglycemia. Impairment of growth and ...
The most common symptoms following an overdose include vomiting, diarrhea, abdominal pain, tachycardia, drowsiness, and rarely, hypoglycemia or hyperglycemia. [98] [99] Treatment of metformin overdose is generally supportive, as no specific antidote is known. Extracorporeal treatments are recommended in severe overdoses. [100]
The ADA (American Diabetes Association) recommends seeing a doctor if blood glucose reaches 13.3 mmol/L (240 mg/dL), [27] and it is recommended to seek emergency treatment at 15 mmol/L (270 mg/dL) blood glucose if Ketones are present. [28] The most common cause of hyperglycemia is diabetes.
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While replacing fluid and electrolyte loss, insulin, and acid-placed balance are the aim of this treatment. [8] proper treatment usually results in full recovery, though death can result from inadequate or delayed treatment, or from complications (e.g., brain edema). [12] Preventing DKA is attainable by following some precautions. [16]
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