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Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, [5]: 6822 [6] is a zymogen, that is, an inactive enzyme.The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other animals.
Protein C is vitamin K-dependent. Patients with Protein C deficiency are at an increased risk of developing skin necrosis while on warfarin. Protein C has a short half life (8 hour) compared with other vitamin K-dependent factors and therefore is rapidly depleted with warfarin initiation, resulting in a transient hypercoagulable state.
4607 17868 Ensembl ENSG00000134571 ENSMUSG00000002100 UniProt Q14896 O70468 RefSeq (mRNA) NM_000256 NM_008653 RefSeq (protein) NP_000247 NP_000247.2 n/a Location (UCSC) Chr 11: 47.33 – 47.35 Mb Chr 2: 90.95 – 90.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. This isoform is ...
2353 14281 Ensembl ENSG00000170345 ENSMUSG00000021250 UniProt P01100 Q6FG41 P01101 RefSeq (mRNA) NM_005252 NM_010234 RefSeq (protein) NP_005243 NP_005243.1 NP_034364 Location (UCSC) Chr 14: 75.28 – 75.28 Mb Chr 12: 85.52 – 85.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is ...
The propeptide of pulmonary surfactant C has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the mature peptide can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has ...
10544 19124 Ensembl ENSG00000101000 ENSMUSG00000027611 UniProt Q9UNN8 Q64695 RefSeq (mRNA) NM_006404 NM_011171 RefSeq (protein) NP_006395 NP_035301 Location (UCSC) Chr 20: 35.17 – 35.22 Mb Chr 2: 155.59 – 155.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans ...
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
PIK3CA-related overgrowth spectrum (PROS) is an umbrella term for rare syndromes characterized by malformations and tissue overgrowth caused by somatic mutations in PIK3CA gene. [ 1 ] [ 2 ] [ 3 ] In PROS diseases individuals malformations are seen in several different tissues such as skin, vasculature, bones, fat and brain tissue depending on ...