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Restless Legs Syndrome Awareness Day is Sept. 23. The condition can make it hard to sleep, but a simple treatment can help.
Both the 2021 algorithm for the treatment of RLS published by members of the Scientific and Medical Advisory Board of the RLS Foundation in the Mayo Clinic Proceedings, [21] and the 2024 American Academy of Sleep Medicine Practice Guidelines [26] recommend the use of low-dose opioids for the treatment of refractory RLS, with the caveat that ...
RLS could be considered either a neurological disorder or a sleep disorder. There have been some genes that have been associated with the disorder, but generally the cause is unknown.
Instead of conventional antidepressant medication in treating depression, treatment with dopamine agonists has been suggested. [9] It is mainly thought that dopamine agonists help with treating depressive symptoms and disorders by alleviating motor complications, which is one of the main symptoms of Parkinson's disease.
Sleep medicine physicians sometimes prescribe tramadol (or other opioid medications) for refractory restless legs syndrome (RLS); [28] [29] that is, RLS that does not respond adequately to treatment with first-line medications such as dopamine agonists (e.g., pramipexole) or gabapentinoids, often due to augmentation. [30]
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