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Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol (THC). It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in Cannabis sativa, [1] [2] but can also be produced synthetically by firstly acid cyclization of cannabidiol and then hydrogenation of tetrahydrocannabinol.
9-Nor-9β-hydroxyhexahydrocannabinol (9-nor-9beta-HHC; sometimes incorrectly confused with 11-nor-9β-hydroxyhexahydrocannabinol [1]) is a cannabinoid first discovered from early modifications to the structure of THC, in a search for the simplest compound that could still fulfill the binding requirements to produce cannabis-like activity. [2] [3]
9-Hydroxyhexahydrocannabinol (9-OH-HHC) is a semi-synthetic derivative of tetrahydrocannabinol. It is formed as an impurity in the synthesis of Delta-8-THC , [ 1 ] and retains activity in animal studies though with only around 1/10 the potency of Δ 9 -THC, with the 9α- and 9β- enantiomers having around the same potency.
Like other 11-OH cannabinoid metabolites, 11-OH-9β-HHC retains activity comparable to HHC itself while the 9α-isomer is significantly less active. [5] However, upon formation it is rapidly metabolized further to the inactive 11-carboxylates, producing a shortened half-life within the body and lowering its bioavailability considerably through ...
The data suggest that for every incident of distribution, possession, or use of alcohol referred to local law enforcement from schools without regular contact with SROs, 1.76 are referred in schools with regular contact with SROs, with p < 0.001. This is after controlling for state statutes that require school officials to refer students to law ...
HHC-P is a partial agonist of the CB1 receptors with an EC50 of 44.4nM for 9R-HHCP and 134nM for 9S-HHCP. Compared to Hexahydrocannabinol (HHC) with an EC50 of 101nM for 9R-HHC and 1,190nM for 9S-HHC [ 5 ] In 2021, HHC-P was positively identified in multiple retail electronic vaping products in the United States.
[2] [3] [4] Typically, synthetic cannabinoids are sprayed onto plant matter [5] and are usually smoked, [6] although they have also been ingested as a concentrated liquid form in the United States and United Kingdom since 2016. [7]
The Safe and Drug-Free Schools and Communities Advisory Committee, authorized by the No Child Left Behind Act, was appointed by the U.S. Secretary of Education Margaret Spellings. The Committee was established to provide advice to the Secretary on Federal, state, and local programs designated to create safe and drug-free schools, and on issues ...