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"The dose makes the poison" (Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison."
The study of poisons and toxic substances has a long history dating back to ancient times, when humans recognized the dangers posed by various natural compounds. However, the formalization and development of toxicology as a distinct scientific discipline can be attributed to notable figures like Paracelsus (1493–1541) and Orfila (1757–1853).
A toxicologist working in a lab (United States, 2008)Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms [1] and the practice of diagnosing and treating exposures to toxins and toxicants.
Paracelsus was born in Egg an der Sihl [], [18] a village close to the Etzel Pass in Einsiedeln, Schwyz.He was born in a house next to a bridge across the Sihl river.His father Wilhelm (d. 1534) was a chemist and physician, an illegitimate descendant of the Swabian noble Georg [] Bombast von Hohenheim (1453–1499), commander of the Order of Saint John in Rohrdorf.
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Title page of Benedictus Figulus's 1608 edition of Kleine Wund-Artzney, based on lecture notes by Basilius Amerbach the Elder (1488–1535) of lectures held by Paracelsus during his stay in Basel (1527). Paracelsianism (also Paracelsism; German: Paracelsismus) was an early modern medical movement based on the theories and therapies of Paracelsus.
Industrial Bio-Test Laboratories (IBT Labs) was an American industrial product safety testing laboratory. [1] [2] [3] IBT conducted significant quantities of research for pharmaceutical companies, chemical manufacturers and other industrial clients; at its height during the 1950s, 1960s, and 1970s, IBT operated the largest facility of its kind and performed more than one-third of all ...
Alexander Oscar Gettler (August 13, 1883 – August 4, 1968) [1] [2] was a toxicologist with the Office of Chief Medical Examiner of the City of New York (OCME) between 1918 and 1959, and the first forensic chemist to be employed in this capacity by a U.S. city. [3] [4] [5] His work at OCME with Charles Norris, the chief medical examiner, created the foundation for modern medicolegal ...