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Protamine sulfate is a medication that is used to reverse the effects of heparin. [3] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery. [3] [4] It is given by injection into a vein. [3] The onset of effects is typically within five ...
Adverse effects include increased pulmonary artery pressure and decrease peripheral blood pressure, myocardial oxygen consumption, cardiac output, and heart rate. [9] Protamine sulfate is an antidote for heparin overdose, but severe allergy may occur. [10]
Two non-hemorrhagic side effects of heparin treatment are known. The first is an elevation of serum aminotransferase levels, which has been reported in as many as 80% of patients receiving heparin. This abnormality is not associated with liver dysfunction, and it disappears after the drug is discontinued.
Hepatin's anticoagulant effects are typically reversible with protamine sulfate, while protamine's effect on LMWH is limited. LMWH has less of an effect on thrombin than heparin, but about the same effect on Factor Xa. Due to its renal clearance, LMWH is contraindicated in patients with kidney disease who can safely use unfractionated heparin.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
A new study found that omega-3 slowed biological aging by up to four months, with vitamin D and strength training boosting the effects: A neurologist explains.
For eight months, the man had been following the carnivore diet — a high-protein, no-carb plan that focuses on eating only animal products, especially meat, eggs and some dairy; and excludes ...
Cardiovascular agents generally have narrow therapeutic indices, implying that small differences in dose or blood concentration may give rise to adverse drug reactions. [45] Serious acute toxicity may result from accidental, intentional or iatrogenic overdose. [46] Therefore, patients need to be aware of any unusual and serious side effects.