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Protamine sulfate is a medication that is used to reverse the effects of heparin. [3] It is specifically used in heparin overdose , in low molecular weight heparin overdose , and to reverse the effects of heparin during delivery and heart surgery .
Because protamine is a fast-acting drug, it is typically given slowly to allow for monitoring of possible reactions. [12] The first step in management of a protamine reaction is to immediately stop the protamine infusion. Corticosteroids are used for all types of protamine reactions. Chlorphenamine is used for type II (anaphylactic) reactions ...
Protamine has been shown to deter increases in body weight and low-density lipoprotein in high-fat diet rats. This effect occurs through the inhibition of lipase activity, an enzyme responsible for triacylglycerol digestion and absorption, resulting in a decrease in the absorption of dietary fat.
Protamine sulfate has been given to counteract the anticoagulant effect of heparin (1 mg per 100 units of heparin that had been given over the past 6 hours). [34] It may be used in those who overdose on heparin or to reverse heparin's effect when it is no longer needed. [35]
Protamine sulfate: Heparin poisoning Prussian blue: Thallium poisoning: Physostigmine sulfate Anticholinergic poisoning Pyridoxine: Isoniazid poisoning, ethylene glycol, accidental hydrazine exposure (E.G from Gyromitra mushrooms) Phytomenadione (vitamin K) and fresh frozen plasma: Warfarin overdose and some (but not all) rodenticides Sodium ...
“The key with snacks is to make sure you are getting [a mix of] healthy fats, protein and fiber to keep you full for longer and provide the fuel your body needs to get through to the next meal ...
Protamine sulfate [51] Table 1: antidotes for cardiovascular agent overdose For patients taking antihyperlipidemic agents, liver function tests have to be conducted before and during the therapy to monitor the elevation of liver enzymes which may result in hepatotoxicity , especially for those undergoing statin therapy . [ 52 ]
A new Clean Label Project report suggests some protein powders contain heavy metals lead and cadmium. See which ones are safe here, plus what an expert advises.