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Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer. [5]
Idiopathic pulmonary fibrosis; Other names: Fibrosing alveolitis, cryptogenic fibrosing alveolitis, diffuse fibrosing alveolitis, usual interstitial pneumonitis, diffuse interstitial pneumonitis: Figure A shows the location of the lungs and airways in the body. The inset image shows a detailed view of the lung's airways and air sacs in cross ...
Myelosuppression, neurotoxicity, pulmonary fibrosis (uncommon/rare), pneumonitis (uncommon/rare), haemolysis (uncommon/rare) and hepatic dysfunction (uncommon/rare). 2. Targeted antineoplastics: 2.1 Monoclonal antibodies: Alemtuzumab: IV: CD52 antibody induces apoptosis in the tagged cells. Chronic lymphocytic leukaemia
[1] [2] These trials aimed to assess the efficacy and safety of ziritaxestat in patients with IPF, including those receiving standard of care treatment with pirfenidone or nintedanib. [1] However, both trials were prematurely terminated due to a lack of efficacy, as ziritaxestat failed to demonstrate significant improvement in lung function or ...
The actual number may be significantly higher due to misdiagnosis. Typically, patients are in their forties and fifties when diagnosed, while the incidence of idiopathic pulmonary fibrosis increases dramatically after age 50. But loss of pulmonary function is commonly ascribed to old age, heart disease, or more common lung diseases. [40]
1. Go Hear a Local Band. It's amazing the talent that goes undiscovered, and they might be in your local pub. 2. Visit a Farmer's Market. This might be seasonal in your area, but it's becoming ...
Jeanne Vaccaro, a scholar and curator from Kansas, always wanted to become a bumper sticker person. For years, she collected stickers from artists, musicians and bookstores, but she kept them away ...
Nintedanib: Triple angiokinase inhibitor, simultaneously blocks VEGFR, FGFR, PDGFR: Idiopathic pulmonary fibrosis (IPF) / non-small cell lung cancer (NSCLC) / ovarian cancer: Phase III Afatinib: Irreversible ErbB family blocker Breast cancer / head and neck cancer. Already approved for non-small cell lung cancer (NSCLC) Phase III Volasertib ...
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