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Self-complementary adeno-associated virus (scAAV) is a viral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. [1] Use of recombinant AAV (rAAV) has been successful in clinical trials addressing a variety of diseases. [ 2 ]
Because of AAV's specialized gene therapy advantages, researchers have created an altered version of AAV termed self-complementary adeno-associated virus (scAAV). Whereas AAV packages a single strand of DNA and must wait for its second strand to be synthesized, scAAV packages two shorter strands that are complementary to each other.
Injury prevention is an effort to prevent or reduce the severity of bodily injuries caused by external mechanisms, such as accidents, before they occur.Injury prevention is a component of safety and public health, and its goal is to improve the health of the population by preventing injuries and hence improving quality of life.
Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of recombinant AAV vectors that enables insertion, deletion or substitution of DNA sequences into the genomes of live mammalian cells.
If the transgene is incorporated into somatic cells, the transgene will stay with the somatic cell line, and thus its host organism. [ 6 ] Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops.
Accident Analysis & Prevention is a bimonthly peer-reviewed public health journal covering accident prevention published by Elsevier on behalf of the Association for the Advancement of Automotive Medicine. The journal was established in 1969 by Frank Haight (University of California, Irvine). [1]
It was found that AAV genome inserts in less than ~10% of occasions AAV infects a cell and the expression is less than when episomally expressed. [4] AAV can only package genomes between 2 – 5.2 kb in size when they are flanked with inverted terminal repeat sequences (ITRs), but optimally holds a genome of 4.1 to 4.9 kb in length. [ 5 ]
Throughout its history, the centre has formed partnerships with key agencies across the field of injury prevention. Its Baseline Research Program is commissioned by Transport for Victoria , the TAC , VicRoads , the Department of Justice , Victoria Police , and the Department of Health and Human Services . [ 4 ]