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Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, [1] is the change in the frequency of an existing gene variant in a population due to random chance. [ 2 ] Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation . [ 3 ]
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a ...
Gene redundancy. Gene redundancy is the existence of multiple genes in the genome of an organism that perform the same function. Gene redundancy can result from gene duplication. [1] Such duplication events are responsible for many sets of paralogous genes. [1] When an individual gene in such a set is disrupted by mutation or targeted knockout ...
Neutral mutation has become a part of the neutral theory of molecular evolution, proposed in the 1960s. This theory suggests that neutral mutations are responsible for a large portion of DNA sequence changes in a species. For example, bovine and human insulin, while differing in amino acid sequence are still able to perform the same function.
Genetic hitchhiking. Genetic hitchhiking, also called genetic draft or the hitchhiking effect, [1] is when an allele changes frequency not because it itself is under natural selection, but because it is near another gene that is undergoing a selective sweep and that is on the same DNA chain. When one gene goes through a selective sweep, any ...
Three major single-chromosome mutations: deletion (1), duplication (2) and inversion (3). In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. [ 1 ] Viral genomes contain either DNA or RNA.
Antigenic variation can occur by altering a variety of surface molecules including proteins and carbohydrates. Antigenic variation can result from gene conversion, [ 1 ] site-specific DNA inversions, [ 2 ] hypermutation, [ 3 ] or recombination of sequence cassettes. [ 4 ] The result is that even a clonal population of pathogens expresses a ...
The mechanisms of evolution focus mainly on mutation, genetic drift, gene flow, non-random mating, and natural selection. Mutation: Mutation [12] is a change in the DNA sequence inside a gene or a chromosome of an organism. Most mutations are deleterious, or neutral; i.e. they can neither harm nor benefit, but can also be beneficial sometimes.