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Protein O-GlcNAc transferase also known as OGT or O-linked N-acetylglucosaminyltransferase is an enzyme (EC 2.4.1.255) that in humans is encoded by the OGT gene. [ 5 ] [ 6 ] OGT catalyzes the addition of the O -GlcNAc post-translational modification to proteins .
O-GlcNAc differs from other forms of protein glycosylation: (i) O-GlcNAc is not elongated or modified to form more complex glycan structures, (ii) O-GlcNAc is almost exclusively found on nuclear and cytoplasmic proteins rather than membrane proteins and secretory proteins, and (iii) O-GlcNAc is a highly dynamic modification that turns over more ...
Two conserved enzymes control this glycosylation of serine and threonine: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). While OGT catalyzes the addition of O-GlcNAc to serine and threonine, OGA catalyzes the hydrolytic cleavage of O-GlcNAc from post-transitionally modified proteins. [14] OGA is a member of the family of hexosaminidases ...
O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O-glycosylation is a post-translational modification that occurs after the protein has been synthesised. In eukaryotes, it occurs in the endoplasmic reticulum, Golgi apparatus and occasionally in the ...
Immune tolerance in pregnancy or maternal immune tolerance is the immune tolerance shown towards the fetus and placenta during pregnancy. This tolerance counters the immune response that would normally result in the rejection of something foreign in the body, as can happen in cases of spontaneous abortion. [1][2] It is studied within the field ...
It is typically the first monosaccharide that connects serine or threonine in particular forms of protein O -glycosylation. N -Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals.
View/Edit Human. Pregnancy-specific beta-1-glycoprotein 1 (PSBG-1) also known as CD66f (Cluster of Differentiation 66f), is a protein that in humans is encoded by the PSG1 gene and is a member of the carcinoembryonic antigen (CEA) gene family. [3] Pregnancy-specific glycoproteins (PSGs) are a complex consisting of carbohydrate and protein ...
Oligosaccharyltransferase or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14- sugar oligosaccharide from dolichol to nascent protein. It is a type of glycosyltransferase. The sugar Glc 3 Man 9 GlcNAc 2 (where Glc= Glucose, Man= Mannose, and GlcNAc= N -acetylglucosamine) is attached to an asparagine (Asn) residue in the ...