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Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli which was first characterized in 1975. [1] [2] Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, and is potentially genotoxic.
Food products and household items commonly handled by humans can be toxic to dogs. The symptoms can range from simple irritation to digestion issues, behavioral changes, and even death. The categories of common items ingested by dogs include food products, human medication, household detergents, indoor and outdoor toxic plants, and rat poison. [1]
In addition to bufotenin, Bufo secretions also contain digoxin-like cardiac glycosides, and ingestion of these toxins can be fatal. Ingestion of Bufo toad poison and eggs by humans has resulted in several reported cases of poisoning, [22] [23] [24] some of which resulted in death. A court case in Spain, involving a physician who dosed people ...
"Chemically Different Tremorgenic Mycotoxins in Isolates of Penicillium paxilli from Australia and North America". Journal of Natural Products . 42 (5): 534–6.
The toxic effects of aconitine have been tested in a variety of animals, including mammals (dog, cat, guinea pig, mouse, rat and rabbit), frogs and pigeons. Depending on the route of exposure, the observed toxic effects were local anesthetic effect, diarrhea , convulsions , arrhythmias or death.
Chocolate is a common cause of poisoning in dogs. The toxic principles in chocolate are theobromine and caffeine. Baker's chocolate is the most dangerous form since it contains higher concentrations of these drugs, followed by semi-sweet, dark, and then milk chocolate. Signs include vomiting, diarrhea, tremors, difficulty walking, seizures, and ...
The toad's primary defense system is glands that produce a poison that may be potent enough to kill a grown dog. [12] These parotoid glands also produce 5-methoxy-dimethyltryptamine (5-MeO-DMT) [13] and bufotenin (which is named after the Bufo genus of toads); both of these chemicals belong to the family of hallucinogenic tryptamines. Bufotenin ...
Biosynthesis pathway of fumitremorgin pathway involves several different enzymes. FtmA is a nonribosomal peptide synthase. Both FtmB and FtmH are prenyltransferase.Three different cytochrome P450 monooxygenases involved in the biosynthesis of furmitremorgin C are FtmC, FtmE, and FtmG.