Search results
Results from the WOW.Com Content Network
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein [5] found on the surface of many immune cells (white blood cells), including CD4 +, CD8 +, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. [6]
Also known as Lymphocyte antigen 75 (LY75), a protein that in humans is encoded by the LY75 gene. Also known as DEC-205. CD206: Also known as Mannose receptor C-type 1 (MC1) and present on the surface of macrophages, immature dendritic cells, and surface of skin cells such as human dermal fibroblasts and keratinocytes. Additional functions ...
CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. During B cell lymphopoiesis, CD19 surface expression starts during immunoglobulin (Ig) gene rearrangement, which coincides during B lineage commitment from hematopoietic stem cell. [8]
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
CD34 is expressed in hematopoietic progenitor cells and endothelial cells of blood vessels. Thus, it has been used as a marker for capillaries and blood vessels. One of the most densely vascular organs is the kidney, wherein networks of capillaries are intertwined with renal tubules.
CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. [5] When activated, NKT cells rapidly produce Th1 and Th2 cytokines , typically represented by interferon-gamma and interleukin 4 production.
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.CD47 belongs to the immunoglobulin superfamily [5] and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha (). [6]