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The Free Thyroxine Index (FTI or T7) is obtained by multiplying the total T 4 with T 3 uptake. [2] FTI is considered to be a more reliable indicator of thyroid status in the presence of abnormalities in plasma protein binding. [2] This test is rarely used now that reliable free thyroxine and free triiodothyronine assays are routinely available.
Thyroxine, also known as T 4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3 ). [ 1 ]
They can also be measured as total T 3 and total T 4, which depend on the amount that is bound to thyroxine-binding globulin (TBG). [74] A related parameter is the free thyroxine index, which is total T 4 multiplied by thyroid hormone uptake, which, in turn, is a measure of the unbound TBG. [75]
Attempts to correct for changes in thyroid binding globulin due to liver disease, protein losing states, pregnancy or various drugs [citation needed]. It is used to calculate free thyroxine index (total T4 x T3 uptake), an estimate of free T4.
The Thyrotroph Thyroid Hormone Sensitivity Index (abbreviated TTSI, also referred to as Thyrotroph T4 Resistance Index or TT4RI) is a calculated structure parameter of thyroid homeostasis. It was originally developed to deliver a method for fast screening for resistance to thyroid hormone .
Jostel's TSH index (TSHI or JTI), also referred to as Jostel's thyrotropin index or Thyroid Function index (TFI), is a method for estimating the thyrotropic (i.e. thyroid stimulating) function of the anterior pituitary lobe in a quantitative way. [1] [2] The equation has been derived from the logarithmic standard model of thyroid homeostasis.
The two thyroid hormones are Thyroxine (T 4) and Tri-iodothyronine (T 3). T 4 and T 3 can be measured by their total amount, or free amount. As the free amount reflects the amount available to body tissues, the most treatment-relevant measures for thyroid disorders are Free T 3 and Free T 4. [68]
Thyroxine-binding globulin (TBG) is a globulin protein encoded by the SERPINA7 gene in humans. TBG binds thyroid hormones in circulation . It is one of three transport proteins (along with transthyretin and serum albumin ) responsible for carrying the thyroid hormones thyroxine (T 4 ) and triiodothyronine (T 3 ) in the bloodstream.