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3-(Trifluoromethyl)aniline is an organic compound with the formula CF 3 C 6 H 4 NH 2. It is one of three isomers of trifluoromethylaniline. It is one of three isomers of trifluoromethylaniline. Classified as an aromatic amines , they are colorless liquids.
The distribution coefficient, log D, is the ratio of the sum of the concentrations of all forms of the compound (ionized plus un-ionized) in each of the two phases, one essentially always aqueous; as such, it depends on the pH of the aqueous phase, and log D = log P for non-ionizable compounds at any pH.
The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H 3 C – CF 3, and hexafluoroacetone F 3 C –CO– CF 3.
Many CF 3-containing metal complexes have been prepared, and some are useful for trifluoromethylation. The most obvious reagent is CF 3 Li, which can be generated by lithium-iodide exchange. This compound is however unstable even at low temperatures. It degrades to lithium fluoride and difluorocarbene. Trifluoromethyl copper(I) reagents are ...
If different species occur in the octanol-water system by dissociation or association, several P-values and one D-value exist for the system. If, on the other hand, the substance is only present in a single species, the P and D values are identical. P is usually expressed as a common logarithm, i.e. Log P (also Log P ow or, less frequently, Log ...
Its pK a value in water cannot be accurately determined but in acetonitrile it has been estimated as −0.10 and in 1,2-dichloroethane −12.3 (relative to the pK a value of 2,4,6-trinitrophenol (picric acid), anchored to zero to crudely approximate the aqueous pK a scale [2]), making it more acidic than triflic acid (pK a MeCN = 0.70, pK a DCE ...
A derivative of trifluorotoluene, 3-aminobenzotrifluoride, is the precursor to the herbicide fluometuron. [3] It is synthesized via nitration followed by reduction to meta-H 2 NC 6 H 4 CF 3. This aniline is then converted to the urea. Flumetramide (6-[4-(trifluoromethyl)phenyl]morpholin-3-one), a skeletal muscle relaxant, is also prepared from ...
Target organs: central nervous system, kidneys, liver. Irritancy: eyes, respiratory tract, skin [3] In the troposphere, PCBTF has an estimated half-life of 67 days. It is transformed by reaction with photochemically-produced hydroxyl radicals to give mainly 2-chloro-5-trifluoromethylphenol. [2]