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Fifth disease, also known as erythema infectiosum and slapped cheek syndrome, [3] is a common and contagious disease caused by infection with parvovirus B19. [4] This virus was discovered in 1975 and can cause other diseases besides fifth disease. [5] Fifth disease typically presents as a rash and is most common in children.
Arthralgias and arthritis are commonly reported in association with parvovirus B19 infection in adults in the absence of skin findings, whereas erythema infectiosum is the main symptom observed in children. The occurrence of arthralgia coincides with the initial detection of circulating IgM- and IgG-antibodies against the viral structural ...
Erythema (Ancient Greek: ἐρύθημα, from Greek erythros 'red') is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. [1] It occurs with any skin injury, infection, or inflammation .
Erythema infectiosum, identified as a distinct condition in 1896. [13] "fifth disease" parvovirus B19: Confluent erythematous and edematous patches on cheeks ("slapped cheek") for 1-4 days followed by a "lacy," reticular, erythematous rash on the body. Roseola infantum (exanthem subitum) "sixth disease" HHV-6 and HHV-7
Erythema infectiosum (Fifth disease) No Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) Exanthem subitum (Sixth disease) No Fasciola hepatica and Fasciola gigantica: Fasciolasis: No Fasciolopsis buski: Fasciolopsiasis: No PRNP: Fatal familial insomnia (FFI) No Filarioidea superfamily: Filariasis: No Clostridium perfringens
The differential diagnoses are: acrodermatitis enteropathica, erythema infectiosum, erythema multiforme, hand-foot-and-mouth disease, Henoch–Schönlein purpura, Kawasaki disease, lichen planus, papular urticaria, papular purpuric gloves and socks syndrome, and scabies. [citation needed]
Erythema toxicum neonatorum is a common, non-threatening rash in newborns. [ 1 ] [ 2 ] It appears in 40-70% of newborns within the first week of life, and it typically improves within 1–2 weeks. [ 2 ] [ 3 ] [ 4 ] It only occurs during the newborn period, but may appear slightly later in premature babies.
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