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As oil solutions by intramuscular injection, the elimination half-lives of testosterone esters are 0.8 days for testosterone propionate, 4.5 days for testosterone enanthate, 20.9 days (in tea seed oil) and 33.9 days (in caster oil) for testosterone undecanoate, and 29.5 days for testosterone buciclate.
In addition, with intramuscular injection, AAS esters are absorbed more slowly into the body, further improving the elimination half-life. Aside from differences in pharmacokinetics (e.g., duration), these esters essentially have the same effects as the parent drugs. [1] They are used in androgen replacement therapy (ART), among other indications.
The following major testosterone ester has not been marketed: [1] [2] Testosterone buciclate (20 Aet-1, CDB-1781) – a very long-acting testosterone ester that was under development but ultimately did not reach the market [4] [5] And the following less commonly known testosterone esters have also not been marketed: [1] [2]
Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. [27] [7] [8] Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.
Testosterone propionate/testosterone enanthate ... List of sex-hormonal medications available in the United States ... List of steroid esters; List of marketed ...
The different testosterone esters provide for different elimination half-lives in the body. Esterification of testosterone provides for a sustained but non-linear release of testosterone hormone from the injection depot into the circulation. Sustanon 100 is administered once every 2 weeks and Sustanon 250 is administered once every 3 to 4 weeks ...
[4] [5] The medication has not been marketed as a single-drug preparation. [4] Testosterone decanoate has been investigated as a potential long-acting injectable male contraceptive . [ 4 ] [ 6 ] [ 7 ] [ 8 ] It has a longer duration of action than testosterone enanthate , but its duration is not as prolonged as that of testosterone undecanoate .
The elimination half-life of DHT in the body (53 minutes) is longer than that of testosterone (34 minutes), and this may account for some of the difference in their potency. [51] A study of transdermal (patches) DHT and testosterone treatment reported terminal half-lives of 2.83 hours and 1.29 hours, respectively. [52]