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Rabies has a long history of association with dogs. The first written record of rabies is in the Codex of Eshnunna (c. 1930 BC), which dictates that the owner of a dog showing symptoms of rabies should take preventive measure against bites. If a person was bitten by a rabid dog and later died, the owner was fined heavily. [31]
The number of recorded human deaths from rabies in the United States has dropped from 100 or more annually in the early 20th century to one or two per year because of widespread vaccination of domestic dogs and cats and the development of human vaccines and immunoglobulin treatments.
3D still showing rabies virus structure. Rhabdoviruses have helical symmetry, so their infectious particles are approximately cylindrical in shape. They are characterized by an extremely broad host spectrum ranging from plants [citation needed] to insects [citation needed] and mammals; human-infecting viruses more commonly have icosahedral symmetry and take shapes approximating regular polyhedra.
On a global scale, however, the World Health Organization reports that dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans.
In 1885, nine-year-old Meister was badly bitten by a supposedly rabid dog. After consulting with Alfred Vulpian and Jacques-Joseph Grancher and obtaining their assistance, Louis Pasteur agreed to inoculate the boy with spinal tissue from rabid rabbits, which he had successfully used to prevent rabies in dogs. [1]
Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs. Parasitol Res. 2010 Aug;107(3):735-9. doi: 10.1007/s00436-010-1930-y ...
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According to statistics provided by the American Society for the Prevention of Cruelty to Animals®, 6.3 million companion animals enter U.S. animal shelters nationwide every year: 3.1 million ...