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Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
(To meet the criteria for PCOS, doctors will look for at least two of the following symptoms: irregular cycles, multiple small cysts on the ovaries, and a raised level of testosterone.) Estrogen ...
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. [14] The syndrome is named after cysts which form on the ovaries of some women with this condition, though this is not a universal symptom, and not the underlying cause of the disorder.
For instance, with PCOS, high levels of insulin and testosterone can increase appetite and promote fat storage, particularly around the midsection. ... medication and possibly hormone therapy ...
People with PCOS typically have an excess of androgens like testosterone. Insulin: Many women with PCOS have insulin resistance, which means their cells don't respond effectively to insulin.
Women with hyperthecosis often have more markedly elevated testosterone, more hirsutism, and are much more likely to be virilized. [4] While elevated androgens in postmenopausal women is rare, [5] hyperthecosis can present in both premenopausal or postmenopausal women. Women with hyperthecosis may or may not have always had underlying PCOS. [6]
Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions.
The increased circulating levels of insulin in PCOS have direct effects on the ovaries, including excess testosterone production and anovulation (a condition where ovulation doesn’t happen ...