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A transmembrane domain (TMD, TM domain) is a membrane-spanning protein domain.TMDs may consist of one or several alpha-helices or a transmembrane beta barrel.Because the interior of the lipid bilayer is hydrophobic, the amino acid residues in TMDs are often hydrophobic, although proteins such as membrane pumps and ion channels can contain polar residues.
Constituent amino-acids can be analyzed to predict secondary, tertiary and quaternary protein structure. This list of protein structure prediction software summarizes notable used software tools in protein structure prediction, including homology modeling, protein threading, ab initio methods, secondary structure prediction, and transmembrane helix and signal peptide prediction.
This causes the cross-prediction between them, which is a weakness of many transmembrane topology predictors. By predicting signal peptides and transmembrane helices simultaneously (Phobius [14]), the errors caused by cross-prediction are reduced and the performance is substantially increased. Another feature used to increase the accuracy of ...
The database provides information about the individual proteins including computationally generated three-dimensional models of their transmembrane alpha-helices spatially arranged in the membrane, topology, intracellular localizations, amino acid sequences, domain architecture, functional annotation and available experimental structures from ...
Translucent concrete (also: light-transmitting concrete) is a concrete based building material with light-transmissive properties due to embedded light optical elements — usually optical fibers. Light is conducted through the stone from one end to the other. Therefore, the fibers have to go through the whole object.
Cis-interactions is when claudins on the same membrane interact, one way they interact is by transmembrane domain having molecular interactions. [7] Trans-interaction is when claudins of neighboring cells interact through their extracellular loops. [ 8 ]
Schematic diagram of the 2D structure of aquaporin 1 depicting the six transmembrane alpha-helices and the five interhelical loop regions A-E The 3D structure of aquaporin Z highlighting the 'hourglass'-shaped water channel that cuts through the center of the protein. Aquaporin proteins are composed of a bundle of six transmembrane α-helices ...
A wave-dissipating concrete block is a naturally or manually interlocking concrete structure designed and employed to minimize the effects of wave action upon shores and shoreline structures, such as quays and jetties. One of the earliest designs is the Tetrapod, invented in 1950.