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The commonly used epinephrine autoinjector delivers a 0.3 mg epinephrine injection (0.3 mL, 1:1000). [citation needed] It is indicated in the emergency treatment of allergic reactions, including anaphylaxis to stings, contrast agents, medicines, or people with a history of anaphylactic reactions to known triggers.
Racepinefrine (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name), or racepinephrine, sold under the brand name Vaponefrin among others, is a sympathomimetic medication described as a vasoconstrictor, bronchodilator, cardiostimulant, mydriatic, and antiglaucoma agent.
An epinephrine autoinjector (or adrenaline autoinjector, also known by the trademark EpiPen) is a medical device for injecting a measured dose or doses of epinephrine (adrenaline) by means of autoinjector technology. It is most often used for the treatment of anaphylaxis. The first epinephrine autoinjector was brought to market in 1983.
The US Food and Drug Administration approved the first nasal spray epinephrine drug for severe allergic reactions known as anaphylaxis, providing a needle-free alternative to EpiPens and similar ...
"The results from this Phase 1 study are very encouraging," said Dr. Julie Wang, MD, Professor of Pediatrics at Icahn School of Medicine at Mount Sinai, "IN-001 not only demonstrates rapid absorption and sustained efficacy, but it also addresses many of the concerns with traditional epinephrine delivery systems, such as needle phobia and ...
Epinephrine 1:1,000 for anaphylaxis and epinephrine 1:10,000 for cardiac arrest; Dextrose 50%, dextrose 25%, and glucagon for hypoglycemia; Naloxone for opioid overdoses; Nitrous oxide for pain management; Inhaled beta agonist medications (e.g. albuterol and ipratropium) for respiratory emergencies caused by asthma, COPD, etc. [3]
It triggers a series of responses after the body releases chemicals named noradrenaline and epinephrine. [1] These chemicals will act on adrenergic receptors , with subtypes Alpha-1 , Alpha-2 , Beta-1 , Beta-2 , Beta-3 , which ultimately allow the body to trigger a "fight-or-flight" response to handle external stress. [ 1 ]
Many tricyclic antidepressants, tetracyclic antidepressants, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole antagonize α 1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.