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Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Taking too much vitamin D. ... potentially very serious risks and side effects when taken in excess,” Stevens wrote. ... Supplements recommends daily vitamin D intakes of 600 IU (15 mcg) for ...
Some effects of vitamin D occur too rapidly to be explained by its influence on gene transcription. For example, calcitriol triggers rapid calcium uptake (within 1-10 minutes) by a variety of cells. These non-genomic actions may involve membrane-bound receptors like PDIA3. [205] [206] [207]
Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [ 3 ] to prevent and treat vitamin D deficiency [ 4 ] due to poor absorption by the intestines or liver disease . [ 5 ]
There's lots of confusion around the difference between vitamin D2 and vitamin D3, and which is best for whom. Doctors and experts explain.
Patients with severe vitamin D deficiency will require treatment with a loading dose; its magnitude can be calculated based on the actual serum 25-hydroxy-vitamin D level and body weight. [ 26 ] There are conflicting reports concerning the relative effectiveness of cholecalciferol (D 3 ) versus ergocalciferol (D 2 ), with some studies ...
It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well for osteoporosis in combination with other medications. [ 1 ] [ 2 ] In 2022, the combination, calcium/vitamin D was the 246th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
These two forms of vitamin D are metabolized in the liver and stored as 25-hydroxyvitamin D. [4] Before biological use, the storage form must be converted into an active form. One common active form is 1,25-dihydroxyvitamin D. [4] The term vitamin D in this article means cholecalciferol, ergocalciferol, 25-hydroxyvitamin D, and the active forms ...
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